Our Publications

Discover the latest research findings and contributions from the Protein Material Interface Group.

2024

Re-engineering lysozyme solubility and activity through surfactant complexation

Carmali, S., et al.

Materials Advances, 2024

This study explores how hydrophobic ion-pairing with two surfactants, SDS and DOSS, alters lysozyme’s solubility, structure, and activity. It finds that sub-stoichiometric SDS enhances catalytic activity by increasing backbone flexibility and active site exposure, while DOSS preserves native structure and function, both offering potential for oral biotherapeutic formulation.

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Computational Prediction of Bioconjugation Sites in Therapeutic Proteins

Carmali, S., et al.

Nature Biotechnology, 2024

We introduce PRELYM, a novel computational tool that accurately predicts lysine reactivity on protein surfaces, enabling rational design of bioconjugation strategies for therapeutic proteins.

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2023

Responsive Protein Nanocages for Targeted Drug Delivery

Carmali, S., et al.

ACS Nano, 2023

This study presents the development of self-assembling protein nanocages that respond to specific biological stimuli, offering a sophisticated platform for targeted drug delivery and release.

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For a comprehensive list, please refer to Dr. Carmali's QUB Pure Profile or Google Scholar Profile. (Links to be updated)