Our Research Focus
Our research is centered on the rational design and engineering of protein-material interfaces to create innovative therapeutic delivery systems with predictable behavior and enhanced efficacy.
Predictable Protein-Polymer Bioconjugation
We aim to achieve precise control over protein modification by developing and applying site-specific, structure-guided bioconjugation strategies. This involves:
- Utilizing computational tools, such as our in-house PRELYM software, for accurate prediction of reaction outcomes at protein surfaces.
- Designing conjugation methods that allow for meticulous control over the site and density of polymer attachment to proteins.
- Investigating the impact of specific modifications on protein structure, stability, and function.
Responsive Protein Systems
Our group explores the creation of protein-based systems that can respond to specific physiological cues for targeted action. Key aspects include:
- Elucidating structure-activity relationships in chemically modified proteins to tune their responsiveness.
- Engineering protein nanocages that can assemble or disassemble in response to environmental triggers (e.g., pH, enzymes).
- Developing "chemical zymogens" – pro-drug versions of therapeutic proteins activated only at the target site, minimizing off-target effects.
- Modulating protein conformation and function through precise chemical modifications for controlled therapeutic release.
Nanostructured Therapeutic Carriers
We focus on developing advanced nanocarriers that protect therapeutic proteins and enhance their delivery. This research involves:
- Studying surfactant-protein interactions to tailor protein characteristics for optimal formulation and activity.
- Innovating "protein-friendly" nanoparticle production processes that maintain the integrity and bioactivity of delicate biologics.
- Designing nanocarriers that improve the stability and activity of proteins in challenging non-native environments, such as within the body or during storage.
- Investigating targeted delivery mechanisms for these nanostructured carriers.
Support for Our Research
We gratefully acknowledge the generous support from the following organizations that make our research possible.
